Abstract
Summary Ligation of the pancreatic ducts may result in either a slight and transitory elevation of serum alkaline phosphatase or a more significant and prolonged elevation of this enzyme. The initial elevation in enzyme concentration is manifest on the first postoperative day. This phase of the elevation, we believe, can be pancreatic in origin. In some animals a second rise occurs later and this rise may be related to fatty changes in the liver. Another mechanism that may be involved in the production of the elevated serum phosphatase is the pericholangitis that we observed in acute pancreatitis in some of our animals. This pericholangitis in turn may be the mechanism responsible for the obstructive type of jaundice that is seen in some patients with acute pancreatitis and due entirely to an intrahepatic obstruction.
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