Effect of Panax notoginseng Saponins and Major Anti-Obesity Components on Weight Loss.

Xuelian Zhang,Xiaobo Sun,Guibo Sun,Chenyang Zhang,Bin Zhang

doi:10.3389/fphar.2020.601751

Abstract

The prevalence of individuals who are overweight or obese is rising rapidly globally. Currently, majority of drugs used to treat obesity are ineffective or are accompanied by obvious side effects; hence, the options are very limited. Therefore, it is necessary to find more effective and safer anti-obesity drugs. It has been proven in vivo and in vitro that the active ingredient notoginsenosides isolated from traditional Chinese medicine Panax notoginseng (Burk.) F. H. Chen exhibits anti-obesity effects. Notoginsenosides can treat obesity by reducing lipid synthesis, inhibiting adipogenesis, promoting white adipose tissue browning, increasing energy consumption, and improving insulin sensitivity. Although notoginsenosides are potential drugs for the treatment of obesity, their effects and mechanisms have not been analyzed in depth. In this review, the anti-obesity potential and mechanism of action of notoginsenosides were analyzed; thus laying emphasis on the timely prevention and treatment of obesity.

Highlights

Individuals with excess fat accumulation that can impair health are called overweight or obese
This review summarizes the anti-obesity effects and mechanisms of P. notoginseng saponins (PNS), provides research potential for the clinical treatment of obesity and the development of safe and effective anti-obesity drugs
The experimental results (Table 1) of in vivo and in vitro studies showed that many kinds of notoginseng monomer saponins, such as ginsenosides RC, Rg3, and Rg2, can inhibit the proliferation and differentiation of adipocytes, reduce the number of adipocytes, and inhibit the accumulation of lipids in adipocytes by reducing the expression levels of PPARγ, CCAAT/enhancer binding protein (C/EBP), SREBP, and FAS, to achieve anti-obesity effects

Summary

Introduction

Individuals with excess fat accumulation that can impair health are called overweight or obese. The experimental results (Table 1) of in vivo and in vitro studies showed that many kinds of notoginseng monomer saponins, such as ginsenosides RC, Rg3, and Rg2, can inhibit the proliferation and differentiation of adipocytes, reduce the number of adipocytes, and inhibit the accumulation of lipids in adipocytes by reducing the expression levels of PPARγ, C/EBPs, SREBP, and FAS, to achieve anti-obesity effects.

Results

Conclusion