Abstract
The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w. orally) were administrated to diethylnitrosamine (DEN)-induced HCC rats. Results showed that paeonol significantly reduced the serum AST, ALT, ALP, GGT, AFU and liver MDA levels, increased serum WBC, TP, ALB, A/G, TNF-α and IFN-γ and liver antioxidant enzymes activities (SOD, CAT, GSH-Px, GR) in HCC rats. Altogether, these results suggest that the paeonol could effectively decrease oxidative injury and improve immunity function in HCC rats.
Highlights
Hepatocellular carcinoma is the most common and lethal of all cancers
Chemical carcinogens acting through free radical metabolites are associated with many biochemical and molecular changes that induces oxidative stress leading to tumor promotion [8]
A variety of cytotoxic and antiproliferative agents have been tested in hepatocellular carcinoma (HCC) treatment, which are used alone, or in combination with other drugs or other treatment modalities [15]
Summary
Hepatocellular carcinoma is the most common and lethal of all cancers. A diversity of dietary [1], endogenous and environmental [2] stimuli mediate hepatocarcinogenesis. Chemical carcinogens acting through free radical metabolites are associated with many biochemical and molecular changes that induces oxidative stress leading to tumor promotion [8]. Superoxide dismutase (SOD) and catalase (CAT) can counteract the deleterious action of reactive oxygen metabolites and protect from cellular and molecular damage [11]. They can act as anticarcinogens, and inhibitors at initiation and promotion/transformation stage in carcinogenesis. As oxidative stress plays a central role in diethylnitrosamine induced hepatotoxicity, the use of antioxidants would offer better protection to counteract liver damage [14]. It was decided to evaluate the efficacy of Paeonol, a plant flavanoid, as an antioxidant against diethylnitrosamine induced hepatocellular damage
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