Abstract
Radix Paeoniae Alba, a well-known Chinese herbal, has been widely used in Chinese Medicine for thousands of years. Paeoniflorin (PF) has been extensively studied in the last 5 years and shows multiple pharmacological actions. In this paper, we review the relevant literature to know the effect of PF on nervous system (NS). Data sources of PUBMED from January 2012 to April 2015 were searched. Inclusion criteria clearly described the effect of PF on NS. Among 280 articles identified in the literature search, 22 studies met the review inclusion criteria. According to current findings, PF was found to ameliorate the decline of memory and learning capacities among NS-related pharmacological models. In addition, PF shows protective effects on depression, cerebral ischemia injury as well as Parkinson's disease by reliving the pain and improving neural synapse plasticity. The pharmacological targets involve multiple pathways including adenosine A1 receptor, M cholinergic receptor, opiate receptor calcium ion channel, NF-κB, Akt and NGF.
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