Abstract
Daily administration of ethanol in a liquid diet or by intubation were both effective in producing tolerance to the hypothermic effects of ethanol. When p-chlorophenylalanine (p-CPA) was administered in a dose previously demonstrated to maintain extensive brain serotonin (5-HT) depletion, the temperature-lowering effects of ethanol were less pronounced than in corresponding controls. The analysis of the effect of p-CPA on tolerance development took into account both initial body temperature and the degree of hypothermia. This study extends our findings with respect to the inhibitory effect of p-CPA on the development of tolerance to the motor-impairing effects of ethanol, and suggests that 5-HT may have a role in tolerance development to ethanol.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
