Abstract
Ozonated olive oil has been widely used as a local infection therapy to overcome bacterial resistance from antibiotics with systemic administration. However, the disadvantage of systemic antibiotics is it cannot be used in large doses for local infection therapy. Periodontitis is an infectious disease that causes alveolar bone damage. In the periodontitis healing process, osteoblasts and angiogenesis play essential roles in bone regeneration. The study aims to determine the effect of topical application ozonated olive oil to osteoblasts number and angiogenesis of alveolar bone in periodontitis healing process using in vivo study. 32 Sprague Dawley rats were divided into two groups: the treatment and placebo groups, 16 rats in each group. The induction of periodontitis was performed by ligating lower incisor with silk ligature for seven days. The treatment group received ozonated olive oil, and the placebo group received 1 % of CMC-Na twice a day. Four rats from each group were necropsied on day 3, 5, 7, and 14 and then processed into histological sample preparations by hematoxylin-eosin staining and counted the number of osteoblast and blood vessels. All collected data were analyzed using two-way ANOVA and posthoc LSD test. The average number of osteoblasts, blood vessels in the treatment group were significantly higher than the placebo group (p <0.05) either on day 3, 5, 7, and 14. Results showed the ozonated olive oil increase the regeneration of alveolar bone in the periodontitis healing process in Sprague Dawley. Therefore ozonated olive oil has the effect of periodontal tissue regeneration.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.