Abstract
The effect of oxytocin and estrogen on prostaglandin I2(PGI2) release was investigated by using ovariectomized rat uterus, and the relation between PGI2 release and adrenoceptor was also examined. The amount of PGI2 released into the medium was e.stimated by the inhibition of ADP-induced aggregation of rat platelet rich plasma. In uterine slices of ovariectomized rats, PGI2 release into the medium was significantly decreased by estrogen treatment(12hr,24hr), but oxytocin exhibited no effect on PGI2 release from ovariectomized and estrogen-treated rat uterus. In uterine horns in contrast to uterine slices, addition of oxytocin into the medium under a definite load condition caused a significant increase in PGI2 release from estrogen-treated(24hr) uterus. Methoxamine and phentolamine had no influence on PGI2 release from estrogen-treated uterus with or without oxytocin. However, isoproterenol enhanced the basal PGI2 release and further promoted oxytocin-induced PGI2 releasing action. On the other hand, propranolol inhibited PGI2 release from estrogen-treated uterus with or without oxytocin. These results indicate that oxytocin stimulates the release of PGI2 from uterine horns of estrogen-treated rats and that β-receptor in uterus may play an important role in PGI2 releasing action of oxytocin.
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