Effect of oxytocin infusion on reducing the blood loss during abdominal myomectomy: a double-blind randomised controlled trial.

Abstract

To assess the effectiveness and safety of oxytocin to reduce blood loss during abdominal myomectomy. Double-blind randomised controlled trial. Obstetrics and Gynecologic University Medical Centre. Eighty healthy women candidates for abdominal myomectomy. Women were randomly assigned to two groups. In the study group (n=40) oxytocin 30 IU in 500ml normal saline; and in the placebo group (n=40) pure normal saline was administered during myomectomy. The main outcome measureswere peri-operative blood loss and rates of blood transfusion. Estimated intra-operative blood loss. Estimated intra-operative blood loss in the study group (189.5±16.72ml) was significantly lower than the placebo group (692.25±89.93ml) (95% CI 672.54-711.96; P<0.0001).The need for blood transfusion was significantly lower in the study group. Blood transfusions were required for three (7.5%) women in the study group and 10 (25%) women in the placebo group (95% CI 15.5-34.5; P<0.001). Intra-operative oxytocin infusion appears to be safe and effective in decreasing blood loss during abdominal myomectomy. Intra-operative oxytocin is effective in decreasing blood loss during abdominal myomectomy.