Effect of Oxysophocarpine on Proliferation and Invasion of Endometrial Cancer HEC-1-B Cells and Related Proteins

Abstract

Endometrial cancer is one of the most common cancer of the female reproductive tract, which has been one of the primary causes of cancer related deaths and accounts for approximately ¼ of these patients. In this paper, HEC-1 cell l i n e s that are known to propagate endometrial cancer have been considered as potential sites of action for various therapeutic agents in an attempt to combat proliferation. Ancient Chinese remedies are by far the most recognized therapeutic method which have been found to relieve patients suffering from a tumor and also suppresses tumor growth. This study researches the effect of an injection formulation of the compound Kushen, which is a large oxysophocarpine-associated compound. In CKI- handled tumor cells, cellular proliferation through DNA synthesis and mobile differentiation seems to be a surprisingly modified mechanism. Cell cycle inhibition is seen to be one of the key mechanisms in CKI mediated tumor suppression in most instances. This is based on the fact that aggregates display certain 2-D specifications and dimerization of genes within the proposed mechanisms [10]. There is, nevertheless, little to no proof that oxysophocarpine, specifically in endometrial cells HEC-1B, inhibits the growth of most cancers’ cells.