Abstract
Oxidative stress is one of the important causes of abnormal embryonic development, in which reactive oxygen species (ROS) play an important role. Embryonic ROS was generated in various metabolic processes of cells, and ROS level can be affected by different stages of embryonic development and the environment around. Physiological level of ROS can work as a second messenger to participate in signal transduction. However, excessive ROS may cause mitochondrial damage, DNA damage, lipid peroxidation and even cell apoptosis in the embryo, resulting in developmental arrest of the embryo. This review aims to summarize the dual effects of ROS on pre-implantation embryo development and the research progress of the rescue plan after oxidative stress damages the embryo, which will help us get a deeper understanding of the influence of oxidative stress on pre-implantation embryo development, and choose an appropriate rescue plan to avoid the damage of oxidative stress to the pre-implantation embryo development process.
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