Abstract
The effect of ouabain on insulin secretion has been studied in the anesthetized dog. Blood glucose, plasma free fatty acids and plasma amino nitrogen were determined simultaneously. When infused at a dose of 1 μg/kg/min, ouabain significantly reduces blood glucose and plasma free fatty acid levels and increases plasma amino nitrogen. Plasma insulin concentrations are significantly increased in both arterial and pancreaticoduodenal venous blood. The pancreaticoduodenal vein blood flow is not significantly modified. Calculated pancreatic insulin production is markedly increased during ouabain infusion. These findings were confirmed using “one shot” injections of ouabain. The mechanism of the marked in vivo effect of ouabain on insulin production is discussed.
Published Version
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