Abstract
Ouabain (10 −4 M) added to the serosal solution of isolated frog skin not only stops the active transport of Na + but causes a dramatic increase in the electric conductance of the skin. The effect also appears when ouabain is added to amiloride-pretreated skins, ruling out the possibility of a cellular effect. The similarity between the effect of ouabain on normal and amiloride-pretreated skins indicates that no appreciable recycling of Na + across the basolateral membrane of frog skin takes place. The change of Na + efflux after ouabain is added to amiloride-pretreated skins parallels the change of electric conductance, indicating that besides blocking the Na + pump, ouabain affects the paracellular shunt pathway between the cells.
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