Abstract
This contribution describes the nucleation and crystal growth behavior of hydroxyapatite (HAP) crystals grown in agarose and silica hydrogels as well as their characterization via powder X-ray diffraction. The effect of several biological macromolecules such as osteopontin, chondroitin sulfates B and C, and human serum albumin (HSA) on crystal growth behavior of HAP is evaluated. From our results, osteopontin and chondroitin sulfates B and C inhibit the HAP crystal growth in agarose hydrogels. Nevertheless, employing silica hydrogels, only osteopontin inhibits the crystal growth of HAP. On the other hand, HSA does not show any effect on the formation of HAP crystals in both types of hydrogels.
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