Abstract
Objective To evaluate the effect of ORM1 genetic polymorphism on the time-course of muscle relaxation induced by rocuronium. Methods Seventy American Society of Anesthesiologists physical status Ⅰor Ⅱ patients, aged 25-55 yr, scheduled for elective gynecological laparoscopic surgery, with body mass index of 20-25 kg/m2, were enrolled in this study.Anesthesia was induced with iv midazolam and fentanyl and target-controlled infusion of propofol.After the patients lost consciousness, neuromuscular block was assessed with TOF Watch-SX using single stimulation of the ulnar nerve.When the maximal twitch depression was achieved, tracheal intubation was facilitated with rocuronium 0.6 mg/kg.The patients were mechanically ventilated.End-tidal carbon dioxide partial pressure was maintained at 35-45 mmHg.The onset time, nonresponse time, clinical duration, 75% recovery time and recovery index of rocuronium were recorded.Peripheral venous blood samples were collected before surgery for determination of concentrations of plasma alpha1 acid glycoprotein, C-reactive protein(by enzyme-linked immunosorbent assay)and albumin(by biochemical method). ORM1 genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism.The patients were divided into 3 groups according to the ORM1 genotypes: wild homozygote(ORM1*F1/*F1) group (AA group), mutation heterozygote(ORM1*F1/*S) group (AG group)and mutation homozygote(ORM1*S/*S) group (GG group). Results There were 40 cases in group AA, 25 cases in group AG, and 5 cases in group GG.There were no significant differences in plasma alpha1 acid glycoprotein, albumin and C-reactive protein concentrations between the three groups(P>0.05). Compared with group AA, the clinical duration, 75% recovery time and recovery index of rocuronium were significantly prolonged(P 0.05). Conclusion ORM1 genetic polymorphism is one of the genetic factors which affect the time-course of muscle relaxation induced by rocuronium. Key words: Orosomucoid; Polymorphism, single nucleotide; Androstanols; Neuromuscular blockade; Dose-response relationship, drug
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
