Abstract
The effect of the Chinese crude drug “Xiebai” and its components on human platelet aggregation induced by 2 μM ADP was studied. From the ethyl acetate-soluble fraction giving a remarkable inhibitory effect against platelet aggregation, N-P-coumaroyltyramine ( 1) and N-TRANS-feruloyl tyramine ( 2) were isolated as the active principles. Compound 2 showed a strong inhibitory activity against both the primary and secondary wave aggregation induced by 2 μM ADP of human platelet, whereas 1 was effective only against the primary aggregation. In comparison with the above compounds cinnamic acid derivatives ( 3- 6) and tyramine ( 7) were also examined with respect to human platelet aggregation. Compounds 3 and 5 showed the inhibitory activity against both the primary and secondary wave aggregation as did as 2, while 6 inhibited only the primary aggregation, and 4 gave a lower effect. Compound 7 showed inhibition only upon the secondary aggregation.
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