Effect of organophosphorus compounds on the external respiratory functionin rats during intratracheal andintraperitonealadministration

Abstract

Due to the increasing influence of chemical factors on the human body, the experiment has been conducted using organophosphorus compounds (OPC) to stimulate poisoning cases in the production facilities. Given that the development of respiratory failureis a specific organophosphate poisoningsymptom, a comparative analysis of external respiratory function (ERF)in rats with intratracheal and intraperitoneal administration of diisopropyl fluorophosphates (DFP) has been carried out. During the research, the average lethal doses of the toxic chemicals have been established, the conditions of DFP intoxication have been modeled.Thus, LD16 was 0.284 mg/kg by intratracheal administration, 1.6 mg/kg byintraperitoneal administration. Experimental data have shown that the intratracheal intake of OPC causes the development of respiratory failure in the first minutes after poisoning.The return of the ERF indicators to the background values was noted a day after poisoning. With the intraperitoneal administration of the toxic chemical, the rate of development of ERF disorders was lower, toxic effects persisted for two days. The data obtained can be used to make appropriate recommendations for the prevention of accidents and non-emergency cases in a production facility.