Abstract
Many pharmaceutical bulk powders are known to have various solid states, such as polymorphic forms, solvates, and amorphous forms. The amorphous form is known to be recrystallized by absorbing various solvent vapors depending on the chemical properties. It is possible to perform a search for polymorphs of drugs by utilizing this property. In this study, the solvent properties of solvent vapor by using amorphous indomethacin (A-IMC) as a model drug were measured using X-ray diffraction (XRD) in terms of the effect on crystallization. A-IMC was exposed for 2h at 30°C in a sealed container with normal alcohols with different carbon number (ethanol, 1-propanol, 1-butanol, 1-pentanol, and 1-octanol), and changed to the stable crystalline form (γ-IMC) and the metastable form (α-IMC). Exposure to alcohol vapor with a long alkyl chain provided a high yield of the γ-form and a long induction period. It was considered that the rapid generation of crystal nuclei was performed by increasing the polarity of alcohol.
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