Abstract
Crystallization or precipitation of cyclodextrins in the presence of racemates has proven to be a useful method to enrich enantiomers. The technique is commonly performed in neat aqueous solutions which limits its utility in resolving many hydrophobic compounds with poor water solubility. In this work we demonstrate that it is possible to enhance the enantiomeric enrichment of (±)-3-dimethyl-aminopropiophenone using organic cosolvents via β-cyclodextrin precipitation. In addition, an equation that allows the calculation of the production efficiency of an enantiomeric enrichment is proposed and utilized. Water plus various organic solvents, including methanol, ethanol, isopropanol, 1-propanol, tert-butanol, and acetonitrile, are studied as cosolvents. Several factors are investigated in terms of their effect on the enantiomeric enrichment including a) molar ratio of β-cyclodextrin to analyte, b) solubility of the analyte, c) solubility of β-cyclodextrin, d) solution pH, and e) amount of analyte co...
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
