Effect of organic co-solvents on the solvation enthalpies of amino acids and dipeptides in mixed aqueous solutions

Abstract

Transition enthalpies (ΔtrHo) of substances from water to binary solutions were calculated at 298.15 K on the basis of standard dissolution enthalpies (ΔsolHo) for six amino acids and five dipeptides in the mixtures of water with organic solvents of various chemical natures. The enthalpy pair coefficients of interaction hxy for biomolecules with organic component of mixture were estimated within the formalism of the McMillan-Mayer theory. The change in the character of the interaction of the components of solution was demonstrated in dependence on the physicochemical properties of the solvent and nature of the side radical of the dissolved bioorganic substance. Quantitative estimation of the type of interaction of the substance with the solvent was performed on the basis of correlation ratios relating the enthalpy characteristics of bioorganic substances to properties of organic cosolvents. It was shown that in the solutions under study, the effects of both the specific (mainly electron donor) and non-specific solvation of amino acids and peptides are observed.