EFFECT OF ORAL MELATONIN IN ATTENUATION OF HAEMODYNAMIC STRESS RESPONSE DURING ENDOTRACHEAL INTUBATION AND LARYNGOSCOPY IN PATIENTS UNDERGOING ELECTIVE SURGERY UNDER GENERAL ANAESTHESIA: A RANDOMIZED CONTROLLED STUDY.

Abstract

INTRODUCTION: During laryngoscopy and intubation there is an increase in both heart rate and blood pressure due to sympathetic response mediated by catecholamines and activation of tracheal nociceptors due to its manipulation. Melatonin has been used for sleep regulation and ICU sedation but there are very few studies to evaluate its effect on reducing haemodynamic stress response during laryngoscopy and intubation. In our study we evaluated the effects of melatonin in reducing the haemodynamic changes during laryngoscopy and intubation. : 100 patients belonging to ASA grade 1 and 2 of either gender METHODOLOGY , of age 18 to 60 years who were planned for elective surgery under general anaesthesia were randomly divided into two groups: Group M (n=50) was given 6 mg oral melatonin (two capsules of 3 mg each) and Group C (n=50) was given multivitamin capsules with a sip of water 90 minutes before induction of anaesthesia. General anaesthesia was induced using standard method for both the groups and changes in heart rate and blood pressure were noted in pre operative period, during intubation and at 1, 3, 5 and 10 min after intubation. The me RESULTS: an pulse rate was comparable between the two groups at baseline. During intubation heart rate was increased in both groups but rise was signicant in control group which persisted upto10 minutes, while in melatonin group it started settling within 3 minutes. There was a signicant rise in SBP, DBP and MAP in control group during and after intubation till 5 minutes as compared to melatonin group. Oral melat CONCLUSION: onin can be used in pre operative period to effectively reduce the hemodynamic stress response during and after laryngoscopy and intubation.