Abstract
Effect of ingestion of eicosapentaenoic acid-ethyl ester (EPA-E) on natural killer (NK) cell activity in rat spleen was examined. EPA-E ingestion during four weeks (100 mg/kg/day) significantly depressed NK cell activity. After EPA-E ingestion, EPA content in the spleen cell lipids was significantly increased, compared to that in control rat spleen cells, and AA content was not changed. Production of leukotriene B 4 (LTB 4) in spleen cells obtained from rats fed with EPA-E (EPA rats) was significantly decreased, compared to that from control rats. A decreased NK cell activity in spleen cells obtained from EPA rats was recovered by the addition of LTB 4 in a dose-dependent manner. The current data indicate that EPA-E-induced inhibition of NK cell activity is mediated at least partially by the decrease of LTB 4 production.
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