Abstract
The effects of 6 weeks of oral clonidine hydrochloride (0.05 mg b.i.d.) on the cardiovascular response to stressful mental arithmetic (SMA) were studied in menopausal women. There was no significant alteration in resting limb blood flow after oral clonidine. The rise in forearm blood flow during SMA was, however, greater and the return to basal levels after SMA slower in women treated with clonidine than in the initial control test. Hand blood flow and pulse rate changes during SMA were unaffected by clonidine. These findings, in keeping with our previous observations of the change in vascular response to exogenous amines after clonidine therapy, are difficult to explain in terms of an influence of the drug on presynaptic α-adrenergic activity alone. It is therefore possible that clonidine might affect other mechanisms such as peripheral cholinergic activity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
