Abstract
Background: Analgesia, sedation, hemodynamic stability, and improved postoperative outcomes are important for orthopedic surgery. Researchers have found clonidine, a centrally acting partial α2 adrenoceptor agonist serves this well. This study was conducted to find out the effect of oral clonidine on epidural anesthesia in hip replacement surgery.Methods: This open-level, randomized control trial (RCT) was conducted at the Department of Anesthesia, Analgesia, and Intensive Care Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. A total of 60 patients were included in the trial; 30 in the Intervention (clonidine) group and another 30 in the control group (placebo). Sensory block, motor block, visual analog scale (VAS), and vital parameters were assessed. Ethical approval was taken from the institutional review board (IRB) of BSMMU and informed written consent was taken from each participant.Results: The onset of sensory blockade was significantly quick (intervention group vs control group:15.8±1.3 min vs 19.4±2.0 min) and analgesia sustained significantly for a prolonged period (p-value: 0.003) higher in the intervention group (256.1±18.7 min) than the control group (192.9±16.1 min). After 5 and 10 minutes of intervention; significantly (p-value: 0.001) lower systolic blood pressure was observed in the intervention group. And in 15 and 45 minutes, diastolic blood pressure was significantly (p-value: 0.013, 0.001; respectively) higher in the intervention group.Conclusion: Oral clonidine gave early onset and prolonged duration of sensory blocking, analgesia without major hemodynamic instability, and post-operative side effects.
Published Version
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