Effect of oral administration of L‐pipecolic acid on food intake in chicks and mice

Abstract

AbstractIt has been demonstrated that L‐pipecolic acid (L‐PA), a major metabolic intermediate of L‐lysine (L‐Lys) in the brain, is involved in the functioning of the γ‐aminobutyric acid‐ergic system. Previous study has shown that intracerebroventricular injection of L‐PA suppressed feeding and induced sleep‐like behavior in neonatal chicks. The present study examines whether the action of L‐PA was induced by gavage in both chicks and mice. Oral administration of L‐PA significantly inhibited food intake at 2 h after treatment in neonatal chicks, although no significant effect of L‐Lys was detected. In mice, oral L‐PA suppressed food intake compared to the control after 2 h of treatment. It was concluded that L‐PA was effective for suppression of food intake after oral administration in both avian and mammalian species.