Abstract
We read with interest the report by Wong et al. which concluded that there was no association between intrathecal opioid analgesia and OPRM1 variant G allele (118A>G or N40D). 1 Wong C.A. McCarthy R.J. Blouin J. Landau R. Observational study of the effect of mu-opioid receptor genetic polymorphism on intrathecal opioid labor analgesia and post-cesarean delivery analgesia. Int J Obstet Anesth. 2010; 19: 246-253 Abstract Full Text Full Text PDF PubMed Scopus (50) Google Scholar It is a commendable effort which aimed to examine the association of the polymorphism with the duration of intrathecal fentanyl in labouring women and the amount of rescue analgesia for the 72 h following intrathecal morphine injection for planned cesarean deliveries. In replyInternational Journal of Obstetric AnesthesiaVol. 19Issue 4PreviewWe thank Drs Tan and Sia for their comments regarding our labor and postcesarean analgesia studies of polymorphism (304A>G) at the mu-opioid receptor (OPRM1).1 We designed the study to identify differences in pain outcomes between women homozygous for the wild-type allele (304AA) and women hetero- or homozygous for the mutant allele because a previous study by one of us (R.L.) found a significant difference in the ED50 for intrathecal fentanyl for labor analgesia between these two groups.2 As acknowledged in our paper, our negative results differ from those of a study performed in Singapore in a Han Chinese population by Drs Sia and Tan’s group. Full-Text PDF
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