Abstract
This study was performed to examine the effects of ICV injection of antiserum against β-endorphin (β-EP) or methionine-enkephalin (ME) on nitrous oxide-induced antinociception in rats using the hot plate test. The injection of β-EP antiserum reversed the antinociceptive effect of nitrous oxide in a dose-related manner up to 200 μg/rat. However, antagonism of nitrous oxide by 400 μg β-EP antiserum was comparable to that produced by 200 μg. On the other hand, similar amounts of ME antiserum had little effect against nitrous oxide antinociception. These findings suggest that β-EP may play an important role in the antinociceptive effect of nitrous oxide.
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