Abstract
AbstractThirteen nonhuman primates (Macaca mulatta and Madada fascicularis) were placed and maintained on opiates (six on morphine, seven on hydromorphone). Eight nondependent opiate naive primates were used as controls. Noninvasive transrectal electronic stimulation using a Biosonics MEGSRegistered trademark and devices by Biosonics, Inc. Philadelphia, Patents pending. unit was employed to produce erection in all primates. This device has been previously demonstrated to produce consistant, full erections in the species of monkeys employed in these studies. The opiate‐dependent monkeys were tested both after being maintained on the opiates for 150 days, and following a 30‐day washout period (opiate free).The results clearly demonstrate that opiate dependence did not alter the erectile response to rectal stimulation, thus the dependence did not negatively affect the neural or cardiovascular components of the erectile system. Analysis of the results demonstrated although there were no difference between species, there was a significant acquisition effect for the transrectal stimulation procedure.
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