Abstract
Objective Recurrent aphthous stomatitis is one of the most common chronic inflammatory diseases in oral mucosa. Beneficial effects of omega-3 supplements on some inflammatory diseases have been proved. The aim of present study was to evaluate the effect of omega-3 supplements in recurrent aphthous stomatitis management and improve oral health-related quality of life. Methods In this double-blind clinical trial, 40 patients with minor recurrent aphthous stomatitis were randomly divided into case and control groups. The case group received 1000 mg capsules of omega-3, while the control group received placebo capsules for 6 months. The questionnaires of the ulcer severity score and the chronic oral mucosal disease questionnaire were filled by the patients in three steps, at the baseline session, after 3 months, and after 6 months. The data were analyzed by SPSS 22 software through ANOVA, Mann–Whitney, and chi-square tests. P < 0.05 was considered as significant. Results In the omega-3 group, the ulcer severity score showed significant reduction by three-month and six-month follow-ups (P < 0.0001, P < 0.0001, respectively). The mean score of the chronic oral mucosal disease questionnaire significantly improved by three-month and six-month follow-ups in the omega-3-receiving group. Conclusion Use of omega-3 oral supplements decreased the severity of aphthous ulcer and improved oral health-related quality of life.
Highlights
Recurrent aphthous stomatitis (RAS) is one of the most common chronic inflammatory disorders in the oral cavity affecting about 5–25% of the population. e disease is categorized into three clinical variants including minor, major, and herpetiform aphthous, the most common form of which is minor RAS [1,2,3]
Forty individuals with recurrent aphthous stomatitis referring to Babol Faculty of Dentistry were included in the study. ey were randomly divided into two groups: 20 patients in each. e case group received omega-3 capsule while the control group consumed the placebo capsule
From 50 patients with RAS, 10 patients were excluded. 40 remaining patients were divided into two groups randomly. 20 patients were in the omega-3 group, while 20 patients were in the placebo group (Figure 1)
Summary
Recurrent aphthous stomatitis (RAS) is one of the most common chronic inflammatory disorders in the oral cavity affecting about 5–25% of the population. e disease is categorized into three clinical variants including minor, major, and herpetiform aphthous, the most common form of which is minor RAS [1,2,3]. Recurrent aphthous stomatitis (RAS) is one of the most common chronic inflammatory disorders in the oral cavity affecting about 5–25% of the population. Many studies have focused on the association between immunological factors and RAS [6]. E goals of recent therapies are to control pain, improve functional limitations, and reduce the ulcer duration and its recurrence [3, 4]. To achieve these objectives, various topical and systemic medications (corticosteroids, anti-inflammatory medications, immunomodulatory agents, and antiseptic agents) have been used [7,8,9,10]
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