Abstract
Six transmembrane protein of prostate 2 (STAMP2) is a critical modulator of inflammation and metabolism in adipose tissue. There are no data on the expression of STAMP2 in chronic kidney disease, which is an inflammatory disease related to metabolic disorders. This study aimed to investigate STAMP2 expression in the kidney and heart in 5/6 nephrectomy (Nx) rats, and the effect of omega-3 fatty acid (FA) on STAMP2 expression. Male Sprague Dawley rats were divided into three groups: sham control (0.9% saline), 5/6 Nx (0.9% saline), and 5/6 Nx treated with omega-3 FA (300 mg per kg per day by gastric gavage). The expression of STAMP2 in the kidney and heart were examined by western blotting. Serum creatinine levels were higher in 5/6 Nx rats than in controls. Compared with sham controls, the expression of IκB, NF-κB, NOX4, SREBP-1, and LXR were upregulated and STAMP2 and phosphorylated-AMPK expression were downregulated in the kidney and heart of 5/6 Nx rats. Omega-3 FA supplementation prevented these changes in biomarkers related to inflammation and metabolic lipid disorders. Omega 3-FA supplementation induced the upregulation of STAMP2 protein in 5/6 Nx rats, which was associated with an attenuation of inflammation- and metabolic disease-related markers.
Highlights
Persistent inflammation is an important component of chronic kidney disease (CKD) that is related to cardiovascular risk and mortality [1]
Blood urea nitrogen (BUN) and serum creatinine levels were higher in the 5/6 Nx and
Six transmembrane protein of prostate 2 (STAMP2) expression, which was induced by omega-3
Summary
Persistent inflammation is an important component of chronic kidney disease (CKD) that is related to cardiovascular risk and mortality [1]. Metabolic diseases, such as diabetes and dyslipidemia, impact CKD, and many studies have shown the bidirectional relationship between metabolic disease and CKD [2]. There are no definite cross-talking mediators including inflammation and metabolism in CKD, which is inflammatory disease related to metabolic disorders. The six transmembrane protein of prostate (STAMP) protein family, which was initially named six transmembrane epithelial antigens of the prostate, was first reported as a prostate-specific antigen [3]. STAMP2 is expressed in several tissues, including the adipose tissue, lung, placenta, heart, liver, and prostate [3,5]
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