Abstract
Background: Omega-3 fatty acids play an essential role in maintaining cell membranes and anti-inflammatory processes that are in line with vitamin E as a fat-soluble antioxidant that can prevent oxidative stress, inhibit pro-inflammatory cytokines and protect fatty acids from oxidation. This study aimed to determine the effect of omega-3 and vitamin E administration on blood pressure, CRP, and NO levels in PE model pregnant mice. Methods: This study was experimental with the design of the Post Test Only Control Group Design sample of 35 pregnant mice. Measuring instruments use a spectrophotometer. The data were analyzed using the Shapiro Wilks normality test. After the parametric test is met, the hypothesis test uses One Way Anova and LSD. Type Post Hoc Test tests are continued. Result: The results showed that omega-3 and vitamin E administration significantly differed between control groups and treatment of CRP levels (p = 0.001) and NO levels (p = 0.001). Conclusion: Combined administration of omega-3 and vitamin E can lower systole blood pressure, CRP levels, and NO levels; however, there is no decrease in individual administration of diastole blood pressure and NO levels. Keywords: Omega-3, Vitamin E, Oxidative Stress, CRP, NO, Preeclampsia
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