Abstract
Although Mediterranean diet has grown worldwide due to its link with lower cardiovascular disease rate and greater longevity, the effect of olive oil, which is the principal component of Mediterranean diet, on plasminogen activator inhibitor-1 (PAI-1) concentrations in aged rats is not clear. This study was performed on 28 aged male Wistar albino rats allocated into two groups (14 rats each): Olive oil-treated group and the control group. Using Real Time-PCR, the expression of PAI-1 mRNA in the retroperitoneal adipose tissues was decreased significantly in the olive oil treated group versus the control group ( P < 0.01). In parallel, the plasma concentrations of PAI-1 were also reduced significantly in the olive oil treated group versus the control group ( P < 0.01). Olive oil produced significant decrease in mean serum cholesterol and triglycerides in aged rats in the treated group versus the control group ( P < 0.05, P < 0.01, respectively). No significant difference was seen in mean serum LDL-cholesterol or HDL-cholesterol levels between both groups. As regards the BMI, no change was observed after olive oil intake. Our results indicate that olive oil intake may reduce the cardiovascular risk in old age via decreasing PAI-1 at level of gene expression.
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