Effect of oligomerized polyphenol supplementation on lipid metabolism during exercise in healthy men

Abstract

Previous studies have shown that oligomerized polyphenol (OLG) supplementation reduced visceral fat in obese; however, role of OLG on lipid metabolism during exercise has not been tested. Therefore, the purpose of current study was to investigate the effect of OLG supplementation on lipid metabolism during a bout of aerobic exercise. OLG (100mg/day) and placebo (CON) were given for 14 days in 10 healthy young men by a double‐blind, randomized, cross‐over design. After an overnight fast on the 15th day, exercise test (50% VO2max for 30min on bicycle ergometer) was conducted. Blood samples were taken before, during, and up to 30min‐post exercise for analysis of hormones and metabolites. Insulin resistance as assessed by HOMA‐IR tended to be lower in OLG as compared to CON (P=0.09). Plasma glycerol as well as free fatty acid concentration increased significantly 15 to 30min post‐exercise in OLG as compared to CON (P<0.05). Moreover, % change in serum growth hormone was higher in OLG as compared to CON during exercise (P<0.05). In summary, 14 days of OLG supplementation significantly increased exercise‐induced GH response and subsequent lipolysis in response to a bout of aerobic exercise in young men.