Effect of Oligomerised Polyphenol Supplementation on Lipid Metabolism during Aerobic Exercise in Young Subjects

Abstract

PURPOSE: Foods rich in polyphenols, especially flavonoids, have been shown to improve endothelial function, insulin sensitivity, and decrease body fat mass, although mechanisms involved are mostly unknown. Therefore, the purpose of the current study was to determine the short-term (14days) supplementation of oligomerized polyphenol on lipid metabolism during submaximal aerobic exercise in healthy young subjects. METHODS: Eight healthy young males were studied in a double blind manner and given either oligomerized polyphenol (100mg/day) or placebo for 14 days. Before and after the supplementation period, each subject performed an aerobic exercise (30min bicycle ergometer at 50%VO2peak). Blood samples were taken to assess glycerol, free fatty acid, growth hormone, and cortisol to assess the lipid metabolism during and following the bout of exercise. RESULTS: In response to a 30min aerobic exercise, growth hormone and lactate increased significantly during exercise in both groups, while no significant group differences were observed. Free fatty acid tended to increase 15min post-exercise in both groups with no significant group differences. Plasma concentrations of glycerol increased significantly in CON group during exercise, and glycerol concentration of OLG group were even higher as compared to CON at 15min and 30min post-exercise (6.5±0.62 and 15.2±3.64 mg/dl at 15min-post, 5.1±0.83 and 11.8±2.36 mg/dl at 30min-post for CON and OLG, respectively; P<0.05). CONCLUSIONS: In conclusion, supplementation of origomerized polyphenol for 14 days increased glycerol concentration following a bout of moderate-intensity aerobic exercise, indicating an increased lipolysis.FIGURE