Abstract
The desaturation of stearic acid to oleic acid was examined in vitro using 10, 000×g supernatant fraction of the liver specimens biopsied from the patients. The desaturation rates by the liver specimens from the malignant neoplastic cases were relatively lower than those in the nonmalignant cases. The addition of oleic and linoleic acids into the reaction mixture inhibited the desaturation of stearic acid-1-14C by the liver specimens from the non-malignant cases, whereas in the liver specimens from the malignant neoplastic cases such inhibitory effects appeared to be lost.
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