Effect of of ginseng panaxadiol saponin with nitroglycerin and issosorbide dinitrate comepared on myocardial ischaemia

Abstract

Background Previopus studies have demonstrated that ginseng panaxadiol saponin monomer RB1 possess protective effect by endothlin-1 induced myocardial ischaemia Objective This study is examined protective effects of ginseng panaxadiol saponin (PDS) on myocardial ischaemia (MI) which MI were caused by (IH) Method These experiments were used Wistar adult rat of health. ST segment of electrocardiogram (ECG)II was used as the index of (MI). Some other index including heart rate (HR), R ware (mV), QRS (ms), ST (mV), T ware (mV) QT (ms). These indexes recorded as control. Animal moden were made by inject into a vein (IH 10mg/kg, 0.3ml/100g) After 30min, ST segment has depressed more than 0.2mv, which was regarded as a index of MI. Result Meanwhile, QT-prolonged, T and R decreased Normal index were exeamined separately in HR 165.87+/−19.85, R 0.73+/−0.17, QRS 39.61+/−2.58, ST 0, T 0.156+/−0.03, QT 154.55+/−15.60, with application (IH), these index were 177.52+/−13.31, 0.37+/−0.06*, 27.46+/−/−0.71*, −0.275+/−0.03**, 0.113+/−0.06, 176.49+/−10.7, used nitroglycerin 196.85+/−8.12, 0.67+/−1.16, 34.57+/−0.27, −0.05+/−1.53, 0.14+/−0.80, 119.75+/−0.83. used issosorbide dinitrate, were 198.11+/−7.07, 0.42+/−11** 31.85+/−0.04*, −0.06+/−0.01, 0.08+/−0.01*, 152.61+/−0.02, used PDS 100mg/kg, in these index were 199.18+/−2.17**, 0.47+/−0.05*, 32.60+/−0.03, −0.02+/−0.003, 0.20+/−0.04*, 144.03+/−0.11.* Results The results have showed that PDS 100mg/kg can conspicuously antagonize the depression of ST segment model of MI which isopropylarterenol has affected, comparing prominently with those of nitroglycerin and isosorbride dinitrate. P have definite improvements on the depression of T ware (< 0.12mV), and the decreasing of R wave and the elongation of QT intermittence.