Effect of Oenothera paradoxa defatted seed extracts and penta-O-galloyl-β-D-glucose on human polymorphonuclear leukocyte function

Abstract

Polymorphonuclear leukocytes (PMN) are suggested to be implicated in vascular and heart diseases [1]. Particularly, activated PMN produce and release reactive oxygen species (ROS), proteolytic enzymes and neutral endopeptidase (NEP). NEP degrades the atrial natriuretic peptides, which are protective factors in circulation and heart. Previously, we have demonstrated that Oenothera paradoxa defatted seed extracts inhibited the NEP activity on isolated enzyme [2]. In this study, we investigated the effect of those extracts on human PMN function such as: NEP activity inhibition, ROS production and elastase release.