Abstract
The effect of ochratoxin A (OA) on the immune system was investigated in broiler chicks fed graded dietary levels of OA up to 4 ppm for 20 days from hatch. Immunofluorescent demonstration of IgG, IgA and IgM in sections of liver, kidney and lymphoid tissues was used to assess immune competence. Serum immunoglobulin levels were measured by radial immunodiffusion. Ochratoxin caused a significant depression in immunoglobulin-containing cells in all the lymphoid organs studied. Correspondingly, total immunoglobulin levels were also reduced in the sera from OA fed birds, immunosuppression being similar at both the 2 and 4 ppm OA levels. Deposition of immunoglobulins, especially IgG, in the glomerular basement membrane was seen with greater frequency in kidneys from OA fed fowls. Immunoglobulin-containing lymphoid cells occurred more frequently in the kidney parenchyma of these birds.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
