Abstract
Single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) locus are associated with obesity, but lifestyle factors may modulate the obesity risk related to FTO. This study examined the physical activity and dietary patterns of 528 physically active white men and women (mean (SD): 34.9 (9.5) years, 26.6 (4.3) kg·m−2) carrying different risk variants of FTO SNP rs9939609. Sex, age, and anthropometric measurements (stature, body mass, and waist circumference) were self-reported using an online questionnaire, and body mass index and waist-to-height ratio were calculated. Physical activity and eating behaviour were assessed using the International Physical Activity Questionnaire (IPAQ) and Three-Factor Eating Questionnaire (TFEQ), respectively. Body mass, body mass index (BMI), waist circumference, and waist-to-height ratio were not significantly different between individuals expressing different FTO rs9939609 risk variants (all P ≥ 0.66). The cohort was physically active (4516 (3043) total MET min·week−1), although homozygous risk allele carriers (AA) displayed higher TFEQ cognitive restraint compared with nonrisk allele carriers (TT) (ES = 0.33 and P=0.03). In conclusion, obesity-related parameters were not different in physically active individuals expressing different risk variants of FTO rs9939609, although homozygous risk allele carriers exhibited higher cognitive restraint.
Highlights
Obesity is a major risk factor for several chronic diseases and represents a major health and economic burden on society [1]. e aetiology of obesity is multifactorial and is influenced by complex interactions between environmental, lifestyle, and genetic factors [2]
A meta-analysis concluded that higher physical activity levels attenuate the influence of fat mass and obesity-associated gene (FTO) variation on obesity risk by 30% [21], and exercise interventions have demonstrated efficacy in promoting weight loss in FTO risk allele carriers [22, 23]. It is not well understood how the body mass index- (BMI-) increasing influence of FTO is attenuated in physically active individuals
An improved understanding of the differences in dietary and physical activity patterns in variants of FTO rs9939609 Single nucleotide polymorphisms (SNPs) within a physically active cohort may provide a greater insight into the behaviours that offset FTOmediated obesity. erefore, the aim of this study was to examine physical activity and dietary habits in a sample of physically active men and women carrying different risk variants of FTO rs9939609 SNP
Summary
Obesity is a major risk factor for several chronic diseases and represents a major health and economic burden on society [1]. e aetiology of obesity is multifactorial and is influenced by complex interactions between environmental, lifestyle, and genetic factors [2]. A meta-analysis concluded that higher physical activity levels attenuate the influence of FTO variation on obesity risk by 30% [21], and exercise interventions have demonstrated efficacy in promoting weight loss in FTO risk allele carriers [22, 23]. It is not well understood how the body mass index- (BMI-) increasing influence of FTO is attenuated in physically active individuals. An improved understanding of the differences in dietary and physical activity patterns in variants of FTO rs9939609 SNP within a physically active cohort may provide a greater insight into the behaviours that offset FTOmediated obesity. erefore, the aim of this study was to examine physical activity and dietary habits in a sample of physically active men and women carrying different risk variants of FTO rs9939609 SNP
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
