Abstract
Background and aim: Postprandial hyperlipidaemia has been associated with acute cardiovascular effects e.g. endothelial dysfunction and peripheral vasodilatation. Oats have known health benefits, and may reduce the transient, post-prandial endothelial dysfunction. The aim of this short study was to investigate if markers of endothelial function pulse wave velocity (PWV) and augmentation index corrected for heart rate (AIx@75) are affected by a meal with varying levels of saturated fat, with or without oatmeal. Methods and results: Fourteen subjects (aged between 22 and 51 years) were recruited. On their first visit, following baseline measurements of anthropometry, blood pressure (BP), heart rate (HR), PWV and AIx@75, they were given one of three meals (low fat, high fat, and high fat with 60g oatmeal) in a randomised order. Subjects returned three hours later for re-assessment of BP, PWV and AIx@75. Visits two and three followed the same protocol, but only BP, HR, PWV and AIx@75 were measured. There was a significant correlation between baseline PWV and systolic pressure (p<0.02), and AIx@75 and diastolic pressure (p<0.005). AIx@75 was positively related to BMI and waist circumference (p<0.01 and p<0.005 respectively). AIx@75 fell following the high fat meal (p<0.05), but not when oats were taken. Heart rate increased following the high fat meal with oats (p<0.05), but no differences were found between fasting and postprandial PWV after any of the meals. Conclusion: AIx@75 was correlated with BMI and waist circumference. The decrease in AIx@75 following the high fat meal requires further investigation, and AIx@75 is possibly a more sensitive marker of arterial compliance than PWV in a young healthy population.
Highlights
Cardiovascular disease (CVD) is the leading cause of death in the adult population worldwide, with over 7 million related deaths annually
© Copyright iMedPub to investigate if a meal rich in saturated fat with or without oats affects arterial compliance, as measured by pulse wave velocity (PWV) and augmentation index corrected for heart rate (AIx@75)
PWV was correlated with systolic but not diastolic blood pressure (p
Summary
Cardiovascular disease (CVD) is the leading cause of death in the adult population worldwide, with over 7 million related deaths annually. A change in endothelial function is one of the earliest warning signs of cardiovascular disease, which occurs naturally with age [3]. Non-invasive methods such as flow mediated dilatation (FMD), pulse wave velocity (PWV) and pulse wave analysis (PWA) are used identify the risk of CVD, e.g. endothelial dysfunction, arterial compliance, central systolic pressure [4]. Oats have known health benefits, and may reduce the transient, post-prandial endothelial dysfunction. The aim of this short study was to investigate if markers of endothelial function pulse wave velocity (PWV) and augmentation index corrected for heart rate (AIx@75) are affected by a meal with varying levels of saturated fat, with or without oatmeal
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