Abstract
Primary antihapten response to a monovalent conjugate of NIP (4-hydroxy-3-iodo-5-nitrophenylacetic acid) and bovine serum albumin (BSA) tended to be rich in 7S and primary response to a polyvalent conjugate NIP<sub>34</sub>-BSA rich in 19S anti-NIP antibodies. Monovalent conjugate NIP<sub>1.1</sub>-BSA tended to boost cells primed with polyvalent conjugates of NIP to a secondary anti-NIP response rich in 7S and polyvalent conjugate, NIP<sub>34</sub>-BSA, to a response rich in 19S anti-NIP antibodies. Monovalent conjugate, NIP<sub>1.1</sub>-BSA, did not prime the cells detectably, although it induced a primary antihapten response.
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