Abstract
BackgroundNeurotransmitters are involved in several functions in the brain and the body of living things. Changes in the level of neurotransmitters in the brain are associated with several illnesses. Some of the drugs are controlling the neurotransmitter by adjusting the level in the brain and are exclusively used in the treatment of psychological disorders. The purpose of the study was to find out the effect of novel synthesised phenothiazine derivatives (GC1, GC2 and GC8) either alone (7.5 mg/kg or 15 mg/kg, oral) or in combination with amphetamine on the experimental animals.ResultsDopamine level in rat brain was estimated by a spectroscopic method using the UV-visible double beam spectrophotometer at 735 nm. The results revealed that these derivatives blocked the brain dopamine level significantly. The compound GC8 (15 mg/kg) significantly reduced the level of dopamine (0.151 ± 0.04, 0.284 ± 0.03) as similar to that of a standard drug. Furthermore, compounds GC2 (15 mg/kg) and GC1 (15 mg/kg) exhibited a varying level of dopamine inhibition level and have been found at 0.203 ± 0.06 μg/ml, 0.302 ± 0.04 μg/ml, 0.234 ± 0.02 μg/ml and 0.318 ± 0.07 μg/ml, respectively, after the administration of these derivatives either alone or in combination with amphetamine.ConclusionsThe study revealed that the compound 2-amino-6-(3-hydroxy-4-methyl phenyl) pyrimidine-4-yl) (7-chloro-10-(3- (N, N-dimethylamino) propyl)-10H-phenothiazine-3-yl) methanone (GC8, 15 mg/kg) extensively reduced the dopamine level. The order of dopamine-inhibiting effect of the selected compound was found to be GC8 > GC2 > GC1. The increased body weight and relative brain-body weight were also observed in the tested animals due to more intake of food and fluid retention.Graphical abstract
Highlights
Neurotransmitters are involved in several functions in the brain and the body of living things
The result proved that our synthesised compounds controlled the dopaminergic neurotransmitter effectively and brought the behavioural changes in the experimental animals
The obtained result proved that the concentration level of dopamine in rat brain has been decreased by repeated administration of synthesised phenothiazine derivatives (7.5 mg/kg and 15 mg/ kg) by blocking the dopaminergic receptor on the basis of the substituent present in the phenothiazine nucleus
Summary
Neurotransmitters are involved in several functions in the brain and the body of living things. Changes in the level of neurotransmitters in the brain are linked to certain psychological illness, such as schizophrenia, psychomotor diseases, neurodegeneration, hallucinations and Parkinson’s disease [36]. Aforesaid benefits of phenothiazine heterocyclic nucleus promoted us to prepare some derivatives bearing with phenothiazine nucleus and evaluate the dopamine-inhibiting effect These compounds were prepared by modifications of the existing phenothiazine by performing (1) a new substitute at nitrogen element in phenothiazine ring and (2) an introduction of a hetero-aromatic ring. A slight variation in the substitution pattern on the phenothiazine ring often causes distinguishable changes in the biological activities [25] These derivatives controlled the brain dopamine and exclusively used in the treatment of the psychotic disorder [31]. The study stated that there was a significant difference in body weight and relative brain-body weight was observed in the experimental animals during the study period
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Beni-Suef University Journal of Basic and Applied Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
