Abstract
The aim of this study was to evaluate effect of normal saline flush injection into bronchus on creation of decellularized lung scaffolds. Pigs were used: 3 lung grafts for decellularization with pre-treatment of normal saline injection into a bronchus, 3 for decellularization without pre-treatment and 3 treated as normal controls. We compared the characteristics of lung scaffolds created by each method. The pretreatment procedure significantly reduced the DNA content of lung grafts, suggesting effective removal of cellular components. However, this pretreatment also reduced the elastin contents of lung grafts. Considering this characteristic of saline pretreatment, we must continue to look for better methods to produce ideal decellularized lung grafts.
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