Abstract
The effect of norethandrolone (17α-ethyl-19-nortestosterone) on the epiphyseal cartilage of rachitic chicks was investigated in conjunction with the studies of vitamin D3effect on this tissue. Norethandrolone effected a significant decrease in the activity of hexosamine synthetase, but did not alter appreciably the levels of hexosamine or hydroxyproline, nor the activity of alkaline phosphatase.It was noted that norethandrolone exerted a powerful stimulation on the growth of combs of immature chicks. The increased weight of the combs was accompanied by a higher water content. The de-fatted and dried fraction of these combs had an elevated content of hexosamines, while the decrease in hydroxyproline content was noted only after a prolonged treatment with the steroid. Studies with radioactive tracers (Na2S35O4, NaOAc-1-C14) showed an increased rate of incorporation of these potential components of glycosaminoglycans in the de-fatted and dried fraction of the combs. In addition, norethandrolone enhanced the alkaline phosphatase activity in combs.
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