Effect of noradrenaline and angiotensin on blood pressure and cerebral circulation in dogs, following administration via the vertebral artery

Abstract

SummaryThe greatest concentration of radioactive microspheres, injected into the vertebral artery, was found in pons, medulla and cerebellum. Under barbiturate anaesthesia. local administration of angiotensin, 10 ng/kg, or noradre-naline, 100 ng/kg, increased the amount of microspheres arriving in the intracranial structures and decreased the amount arriving in the neck muscles. Under chloralose anaesthesia, angiotensin 10 ng/kg, decreased the amount of microspheres in intracranial and extracranial tissues. This angiotensin-dose did not provoke hypertension.