Year-end Sale % OFF 
Abstract
The effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on the permeability to marker drugs, sulfanilic acid and creatinine, was investigated in rat rectum using the in situ perfusion technique. Indomethacin (IM), phenylbutanone (PB), diclofenac sodium (DF), and aspirin (ASA) were used as NSAIDs. The permeability-enhancing effect increased in the following order : ASA<PB<DF<IM. The effects were reversible. No marked histological changes were observed and, furthermore, protein release from the rectal mucosa was not increased. On the other hand, there was a good correlation between the permeability-enhancing effect and the NSAID amount accumulated in the rectum. Consequently, it is suggested that the accumulation of NSAID in the rectum plays and important role in the enhancement of the rectal permeability to drugs.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
