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Abstract
3 out of 5 animals whereas control and tacrolimus only groups rejected allografts at days 7 1 and 29 2 respectively. Long-term survivors demonstrated durable micro-chimerism in various graft and recipient tissues including skin, lymph node, bone marrow, and spleen. CFSE-MLR data showed unresponsiveness to donor but not to third party allogeneic controls. Secondary skin grafting demonstrated advanced rejection of third party grafts while donormatched grafts were accepted indicating donor-specific immune tolerance.
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