Effect of nonachlazine and oxyfedrine on the coronary blood flow in dogs

Abstract

The coronary blood flow in anesthetized and unanesthetized dogs was measured by means of an ultrasonic Doppler radiotelemetric apparatus. The ultrasonic transducer was placed on the upper third of the descending branch of the left coronary artery. Nonachlazine was shown to increase the coronary blood flow considerably in both anesthetized and unanesthetized dogs. However, the action of the substance lasted only 2–3 min and depended on changes in cardiac activity. Oxyfedrine increased the coronary bllod flow by a lesser degree than nonachlazine but for a longer time (mean 20 min). Considering the high effectiveness of the two substances in clinical practice the authors conclude that the increase in the coronary blood flow is not the main course of action when attempting to obtain an antianginal effect in patients with ischemic heart disease.