Abstract
Background and aim In patients with periodontitis biomarkers in gingival crevicular fluid saliva and serum plasma have been analyzed. In the assessment of oral diseases particularly periodontal diseases saliva has emerged as a potential diagnostic tool. Salivary leptin concentration has not been analyzed in populations with chronic periodontitis to observe changes regarding the effect of periodontal therapy. Therefore the objective of this in vivo interventional study was to evaluate the effect of non-surgical periodontal therapy NSPT on the levels of leptin in individuals with periodontitis.Methodology Twenty four participants included in the study were divided equally between healthy controls n12 and patients with chronic periodontitis n12. Clinical parameters such as probing depth clinical attachment levels plaque index gingival index and modified sulcular bleeding index were measured. Before and one month after periodontal therapy salivary leptin levels were estimated. Using the student t-test statistical analysis was performed.Results During the assay method leptin was detected in all the 24 patient samples. Between healthy subjects and subjects with chronic periodontitis no statistical significant difference in salivary leptin levels was observed. After NSPT clinical parameter evaluation of patients with chronic periodontitis revealed a significant improvement in the periodontal state. However it is necessary to conduct further interventional research with larger sample to establish the significance of salivary leptin in assessing periodontal health.Conclusion This study concludes that leptin level can be used as a biomarker to evaluate the effectiveness of periodontal therapy in chronic periodontitis patients. To establish a correlation more interventional studies with higher sample size may be required to ascertain the role of salivary leptin in evaluating periodontal health status.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
