Abstract
The effect of N-methylpyridinium-2-aldoxime methane sulphonate (P 2S), a drug recommended for prophylactic and therapeutic purposes in organophosphate poisoning, on intestinal (Na-K)ATPase and adenyl cyclase activities, was tested in rats. Intestinal (Na-K)ATPase activity was determined 5 h after intragastric administration of either 0.15 M NaCl or P 2S 200 mg/kg body weight. P 2S decreased significantly jejunal and colonic (Na-K)ATPase activity, 17.1 ± 4.8 (S.E.) and 13.5 ± 3.0, as compared to that in saline-treated rats, 41.5 ± 3.0 (S.E.) and 25.4 ± 1.2 μmol Pi/mg protein per h, respectively. Pretreatment with methyl prednisolone did not prevent the decrease in enzyme activity induced by P 2S. Mucosal PGE 2 and cAMP contents, adenyl cyclase and phosphodiesterase phodiesterase activities, were similar in P 2S and saline-treated rats. It is thus suggested that P 2S-induced inhibition of intestinal (Na-K)ATPase activity might be among the mechanisms contributing to looseness of the stool frequently observed following P 2S administration.
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