Abstract
Streptomyces ambofaciens was grown on a synthetic medium with glycerol (10 g litre −1) and ammonium (20 m m) as carbon and nitrogen sources, respectively. Batch fermentation produced a specific production rate of spiramycin ( q sp) of 0·3 mg h −1 g −1 DCW. Improvement of spiramycin production was achieved by fed-batch culture. The strong influence of the initial uptake rates of glycerol ( q gly) and ammonium ( q NH 4 + ) on the specific production rate of spiramycin ( q sp) was demonstrated by conducting several fermentations with continuous feeding of glycerol and ammonium, in different ratios. The specific production rate of spiramycin was increased 10 fold. A low specific growth rate was also necessary for spiramycin biosynthesis.
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